Additional Proof For Those With Weakened Immune Systems


On Wednesday, November 3, 2021, HealthDay News reported that According to a recent study, transplant patients and some other individuals might need four doses of the COVID-19 vaccination for maximum protection.

Immune systems that the two-dose COVID-19 vaccination has compromised are not sufficiently protected against severe disease in those who have received both doses.

Additional Proof For Those With Weakened Immune Systems

According to the research findings, they should be given a third injection as well as a booster.

In addition, although two doses of mRNA COVID-19 vaccinations are effective in immunocompromised persons, they are much less protected from severe illness than patients with standard immune systems, according to Dr. Peter Emb, the study’s primary author. 

Additional Proof For Those With Weakened Immune Systems

He serves as president of the Regenstrief Institute in Indianapolis and as assistant dean for informatics and health services research at the Indiana University School of Medicine, among other positions.

In a university news release, Emb said that because immunocompromised individuals are less protected after a two-dose series, they should receive an additional dose and a booster, take additional precautions such as wearing a mask when in public, and seek treatment with proven medicines if they become infected.

Persons who are immunocompromised are at a higher risk of experiencing severe COVID-19 consequences. The researchers looked at data from more than 89,000 hospitalizations in nine different states in the United States. In patients with sound immune systems, the two-dose mRNA vaccines from Pfizer and Moderna were 90 percent effective at preventing COVID-related hospitalization.  

According to researchers’ findings, the researchers discovered only 77 percent effective in those with impaired immunity due to various medical disorders.

The researchers also discovered that the efficiency of the immunizations differed dramatically amongst subgroups of immunocompromised individuals. Because of this, the introduction of vaccinations is particularly appreciated among these at-risk populations. 

However, immune system weakness may result from these underlying medical disorders and the therapy that such patients get as part of their overall care plan.

According to current research, persons who suffer from various medical problems may not get the maximal level of protection from known immunizations. Patients with major underlying disorders have largely been excluded from COVID-19 vaccination trials; therefore, it is critical to establish that the COVID-19 vaccines are effective in patients with these problems.

For example, immunizations were shown to be less effective in individuals undergoing organ or stem cell transplantation. According to the results, they were more protective in those who had rheumatologic or inflammatory illnesses than in the general population.

The discrepancies between individuals who had robust immune systems and weaker immune systems were consistent across all age categories, including children.

Researchers have begun enrolling patients at research sites around the United Kingdom. They will compare the study group’s findings to those of control groups of healthy persons who did not have these underlying disorders but did get COVID-19 vaccinations. 

Patient participants in the OCTAVE trial will be those who have received COVID-19 vaccinations as part of the nationwide immunization campaign.


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