[August 12, 2022: Leslie Capo, Louisiana State University Health Sciences Center]
Research reports for the first time a pathway that starts in the gut and ends in brain cells with a powerful pro-inflammatory toxin that contributes to the development of Alzheimer’s disease (AD). (Image credit: Shutterstock)
Research led by Dr. Yuhai Zhao and Walter J. Lukiw of the LSU Health New Orleans Neuroscience Center and Department of Cell Biology and Anatomy, Neurology and Ophthalmology report for the first time a pathway that begins in the gut and involves a potent pro-inflammatory toxin in the brain. ends. Cells that contribute to the development of Alzheimer’s disease (AD). They also suggest an easy way to prevent this from happening. The results are published in Frontiers in Neurology.
The researchers found evidence that a molecule derived from Gram-negative bacteria contained a very potent microbial-borne neurotoxin (lipopolysaccharide, or LPS). bacteroids fragile The human gastrointestinal (GI) tract produces a neurotoxin known as BF-LPS.
“LPS in general are probably the most potent microbial pro-inflammatory neurotoxic glycolipids,” says Dr. Lukiev. “Several labs, including ours, have detected different forms of LPS in neurons of the human brain affected by Alzheimer’s disease.”
In this study, researchers describe the pathway of Bf-LPS from the gut to the brain and its mechanism of action there. BF-LPS exits the gastrointestinal tract, crosses the blood-brain barrier through the circulatory system, and reaches the brain compartments. It then increases inflammation in brain cells and inhibits neuron-specific neurofilament light (NF-L), a protein that supports cell integrity. Deficiency of this protein leads to progressive neuronal cell atrophy and eventual cell death, as seen in AD-affected neurons. They also report that adequate fiber intake can halt the process.
The novel features of this newly described pathological pathway are threefold. The AD stimulating pathway begins within us – in our GI tract microbiome – and is therefore “locally sourced” and active throughout our lives. The highly potent neurotoxin BF-LPS is a natural byproduct of microbial metabolism in the gastrointestinal tract. Bacteroides fragilis The abundance in the microbiome, which is the source of the neurotoxin BF-LPS, can be controlled by dietary fiber intake.
“In other words, a nutrition-based approach to balancing microorganisms in the microbiome aims to alter the abundance, specificity, and complexity of enterotoxigenic forms of AD-relevant microbes and their potential for the pathogenic release of highly neurotoxic microbes.” An attractive medium can be a be secretion containing BF-LPS and other forms of LPS,” explains Lukiev.
The researchers conclude that a better understanding of the interactions between the gastrointestinal-central nervous system axis and the microbiome of the gastrointestinal tract and Alzheimer’s disease will lead to new diagnostic and therapeutic strategies in the clinical management of Alzheimer’s disease and other malignant diseases. There are many ways to do this. Progressive and age-related neurodegenerative diseases.
Analysis of the interaction of hsa-miRNA-30b-5p (miRNA-30b) with the Homo sapiens NF-B 3′-UTR. (Credit: Frontiers in Neurology)
It’s estimated that Americans consume an average of 10-15 grams of fiber per day. The USDA recommends that women consume 25 grams and men 38 grams per day until age 50. Women and men over 50 should consume 21 and 30 grams per day, respectively.
According to the National Institutes of Health, Alzheimer’s disease is the most common diagnosis for patients with dementia and the sixth leading cause of death for Americans. Experts estimate that 5.8 million Americans age 65 and older have Alzheimer’s disease, and its prevalence in the United States is projected to rise to 13.8 million by 2050.
LSU Health New Orleans co-authors include Dr. Vivian Jaber and Nathan Sharpman. Eileen Pogue from Alkem Biotech Research in Toronto, Canada was also a co-author.
The research was supported by LSU Health New Orleans, the Brown Foundation, the Joe and Dorothy Dorset Innovation in Science Health Aging Award, and the National Institutes of Health’s National Institute on Aging.
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Note: Materials provided above by Louisiana State University Health Sciences Center. Content can be edited for style and length.
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