Study Shows That Zinc Also Plays A Vital Role In Controlling Blood Pressure

Study Shows That Zinc Also Plays A Vital Role In Controlling Blood Pressure

Calcium and potassium are crucial in blood pressure management, but a recent study reveals that zinc may also play a role. The researchers uncovered this discovery by chance while researching zinc’s role in rat brain function. If more research supports the study’s results, they might potentially lead to new medications for managing hypertension, or high blood pressure.

Study Shows That Zinc Also Plays A Vital Role In Controlling Blood Pressure

Doctors employ a range of ways to assist patients in managing their hypertension. When exercise and dietary changes, such as increasing potassium consumption and decreasing salt consumption, are insufficient to keep blood pressure below the tolerable range, a variety of medications are available.

Study Shows That Zinc Also Plays A Vital Role In Controlling Blood Pressure

Each of them tries to minimize either cardiac output or peripheral resistance in the body’s vascular system. Relaxing the muscles that surround the arteries and arterioles allows blood to flow more easily, which reduces resistance to blood flow.

According to the authors of a recent study, fundamental studies dating back more than 60 years have demonstrated that the amounts of calcium and potassium in the muscle surrounding blood arteries influence how they expand and contract. However, these researchers discovered that a metal, zinc, may potentially play a role in regulating vascular tone.

Dr. Scott Ayton, Ph.D., senior research author, says: Zinc is an essential metal ion in biology, and considering that calcium and potassium are well known for controlling blood flow and pressure, it’s surprising that the significance of zinc hasn’t previously been recognized.

Dr. Ayton also said that zinc has the opposite impact on blood flow and pressure as calcium does.

Dr. Ashenafi Betrie, Ph.D., is the study’s main author, and Dr. Christine Wright, Ph.D., is a co-senior author. They, along with Dr. Ayton, are all linked with the Florey Institute of Neuroscience and Mental Health in Parkville, Australia, as well as the University of Melbourne in Melbourne, Australia.

According to Dr. Betrie, the revelation that zinc is equally vital was coincidental because they were studying the brain rather than blood pressure.

According to Dr. Betrie, they were studying the effect of zinc-based medicines on brain function in Alzheimer’s disease when they found a significant and unexpected fall in blood pressure in rat models treated with the medications.

The findings of the researchers may explain a handful of things that specialists already know about zinc. For starters, zinc deficiency has been linked to hypertension in animal models. Second, the gene that regulates zinc levels within cells has been related to hypertension and other cardiovascular illnesses.

In human research, however, there is no indication of a relationship between zinc consumption and hypertension. The amount of zinc in circulation is not proportional to the quantity in the cell. The quantity of zinc inside cells was discovered to be crucial in this investigation.

High blood pressure develops when the smooth muscle cells in the walls of the arteries and arterioles contract, restricting the channels through which blood must flow.

As it makes its way through, the blood pushes out the walls of these narrower channels, causing a potentially damaging increase in an outward pressure on them. This can cause blood vessels to be damaged or even burst.

This tightness is caused by calcium in the muscles. In muscular tissue, potassium regulates calcium levels. Both metals’ concentrations are impacted by nearby cells, such as endothelial cells and sensory neurons, which are impacted by the potassium and calcium they contain.

The researchers discovered that zinc affects the muscles, endothelium cells, and sensory neurons all at the same time, lowering calcium levels in the muscles and leading them to relax. As a result, blood circulation increases and blood pressure drops.

The researchers also conducted laboratory studies on selected blood arteries from rats and people and discovered that when intracellular zinc was lowered with a chelator, these arteries constricted.

The researchers also highlight that blood arteries in the heart and brain were shown to be more sensitive to zinc than blood vessels in other parts of the body


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